EPCLUSA (sofosbuvir/velpatasvir) Patient Assistance Program
Don’t let the high cost of brand pan-genotypic chronic hepatitis C therapy disrupt your treatment. We help eligible patients access Epclusa (sofosbuvir/velpatasvir) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey.
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Epclusa (sofosbuvir/velpatasvir) is a once-daily, fixed-dose pan-genotypic direct-acting antiviral (DAA) regimen FDA-approved for chronic hepatitis C virus (HCV) genotypes 1–6 in adults and pediatric patients (≥3 years).
- Without assistance, brand Epclusa costs commonly run approximately $25,000–$28,000 per 28-day supply, with a typical 12-week course commonly $74,000–$84,000+.
- Through AffordMyPrescriptions, qualifying patients can access Epclusa for a flat $69.95 per month — our advocacy team manages the entire enrollment, refills, and renewal process.
- An authorized generic of sofosbuvir/velpatasvir is now available in the U.S. at dramatically lower cost (commonly $24,000/full course list, often much lower with payer programs). Mavyret (glecaprevir/pibrentasvir) is another pan-genotypic combination.
What Is Epclusa Prescription Assistance Program?
The Epclusa Prescription Assistance Program is a manufacturer-sponsored initiative that provides Epclusa at little or no medication cost to qualifying patients based on income and insurance status. The program is designed for chronic hepatitis C patients who are uninsured or underinsured, as well as Medicare Part D beneficiaries.
Navigating the program on your own means dealing with eligibility verification, hepatologist or HCV provider coordination, prior-authorization documentation, and renewal deadlines.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your enrollment, from initial application through ongoing refill coordination and treatment-course completion.
Pharmacy Price Comparison
- Without assistance, brand Epclusa costs roughly $25,000–$28,000/month. A Patient Assistance Program is the meaningful path forward — if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens (brand) | ~$27,000 | Save ~$26,930/mo |
| CVS Pharmacy (brand) | ~$28,000 | Save ~$27,930/mo |
| Walmart (brand) | ~$25,500 | Save ~$25,430/mo |
| Costco (brand) | ~$25,000 | Save ~$24,930/mo |
| Authorized generic | ~$8,000 | Authorized generic |
*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Epclusa Prescription Program?
The Patient Assistance Program is free to apply for and provides Epclusa at no medication cost if approved. Our $69.95/month service covers full advocacy. With the authorized generic of sofosbuvir/velpatasvir widely available at much lower cost, we’ll help your provider determine the best HCV regimen and the lowest-cost path.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Epclusa:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Coupon cards expire and require constant renewal
Still $25,000–$28,000 per month even with the best discount
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly through the assistance program
- We manage all paperwork, refills, and annual renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Epclusa assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Epclusa Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Not sure if you qualify? Our pre-qualification check is completely free. If we can’t help, you won’t be charged.
Understanding Epclusa:
Epclusa(sofosbuvir/velpatasvir) is a once-daily, fixed-dose two-drug pan-genotypic DAA combination for chronic hepatitis C genotypes 1–6. It combines an NS5A inhibitor (velpatasvir) and an NS5B nucleotide polymerase inhibitor (sofosbuvir).
How Epclusa Works:
Epclusa combines two direct-acting antivirals, velpatasvir and sofosbuvir, to target the NS5A and NS5B proteins essential for HCV replication. This dual-action approach blocks viral RNA assembly and polymerase activity, achieving a cure rate of over 95% in treatment-naïve patients. A major clinical benefit is its pan-genotypic activity, which allows it to treat all HCV genotypes without requiring prior genotype testing.
Form and use:
The medication is administered as a single oral tablet taken once daily, with or without food, for a standard duration of 12 weeks. For patients with decompensated cirrhosis, Epclusa is approved for use in combination with ribavirin over the same 12-week period. Most patients achieve a complete cure after completing a single course of treatment.
Generic availability:
An authorized generic of sofosbuvir/velpatasvir is available at a significantly lower cost than the brand-name Epclusa. Other options include Mavyret, which may offer a shorter 8-week course for certain patients. Many Medicaid programs and specialized initiatives have successfully negotiated lower prices to increase access to these hepatitis C cures.
Warnings:
Epclusa carries a critical warning for Hepatitis B reactivation, making HBV testing mandatory before starting therapy to prevent potentially fatal flares. It is also linked to serious bradycardia when co-administered with amiodarone and can be rendered ineffective by strong P-gp or CYP inducers. Additionally, acid-reducing medications like PPIs require specific timing precautions as they can interfere with the absorption of velpatasvir.
FAQ (Frequently Asked Questions)
How Much Does Epclusa Cost Without Insurance?
Brand Epclusa costs approximately $25,000–$28,000 per 28-day supply. Authorized generic sofosbuvir/velpatasvir is dramatically cheaper. Through AffordMyPrescriptions, qualifying patients receive Epclusa at no medication cost — our $69.95 monthly fee covers full advocacy and program management.
What Does 'Pan-Genotypic' Mean?
HCV has six main genotypes (and many sub-genotypes). Older HCV regimens worked only against specific genotypes. Pan-genotypic regimens like Epclusa work against all six — meaning patients can start treatment without genotype testing, and a single regimen covers most cases. Mavyret is the other commonly used pan-genotypic regimen.
Will I Be Cured After Epclusa Treatment?
HCV has six main genotypes (and many sub-genotypes). Older HCV regimens worked only against specific genotypes. Pan-genotypic regimens like Epclusa work against all six — meaning patients can start treatment without genotype testing, and a single regimen covers most cases. Mavyret is the other commonly used pan-genotypic regimen.
Is The Authorized Generic Of Epclusa The Same?
Yes, in most cases. Epclusa cures over 95% of HCV patients across all genotypes in 12 weeks. ‘Cure’ in HCV means sustained virologic response 12 weeks after completing therapy (SVR12) — a durable, treatment-ending outcome.
Can I Get Epclusa Through The PAP If I Have Medicare?
Yes. An authorized generic is the brand product, sold under a different (generic) name and label. The active ingredients, doses, manufacturing, and clinical effect are the same. The authorized generic of sofosbuvir/velpatasvir is widely accepted as clinically equivalent to Epclusa and is substantially cheaper.
What About Acid-Reducing Medications?
Velpatasvir absorption depends on stomach acidity. PPIs (omeprazole, esomeprazole, etc.) should be timed carefully or avoided. H2 blockers (famotidine, ranitidine) and antacids (Tums, Maalox) require timing precautions. Tell your prescriber about all acid-reducing medications, including OTC products.
What If My Application Is Denied?
If denied, we explore alternatives — switching to the authorized generic of sofosbuvir/velpatasvir, Mavyret, state Medicaid for chronic HCV (now widely covered), the manufacturer’s copay program for commercially insured patients, or independent foundations. If we cannot find a path, you won’t be charged our service fee.
Take Control of Your Medication Costs
If you are struggling with the high cost of Epclusa, our team may be able to help you access assistance programs designed to make brand HCV cures affordable. Check your eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.