ADAKVEO (crizanlizumab) Patient Assistance Program
Don’t let the high cost of brand sickle cell pain crisis prevention therapy disrupt your treatment. We help eligible patients access Adakveo (crizanlizumab) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey.
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Adakveo (crizanlizumab-tmca) is FDA-approved to reduce the frequency of vaso-occlusive crises (VOC) in adults and pediatric patients ≥16 years with sickle cell disease (SCD). It is a P-selectin inhibitor given as monthly IV infusion. NOTE: EMA withdrew approval in 2023 after a confirmatory trial failed to show benefit; FDA approval status under review.
- Without assistance, Adakveo costs commonly run approximately $2,500–$4,000 per monthly infusion.
- Through AffordMyPrescriptions, qualifying patients can access Adakveo for a flat $69.95 per month.
- There is no biosimilar of Adakveo. Other SCD therapies: hydroxyurea (generic, very cheap — foundational SCD therapy), L-glutamine (Endari — for VOC prevention), voxelotor (Oxbryta — FDA approval withdrawn 2024 due to safety concerns), and stem cell transplant/gene therapy (Casgevy, Lyfgenia — for severe SCD).
What Is Adakveo Prescription Assistance Program?
Adakveo PAP for SCD patients.
Eligibility, hematology coordination.
AffordMyPrescriptions eliminates that burden. $69.95/month advocacy.
Pharmacy Price Comparison
- Adakveo $2,500–$4,000/infusion. PAP can help:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$3,800/dose | Save ~$3,730/dose |
| CVS Pharmacy | ~$4,000/dose | Save ~$3,930/dose |
| Walmart | ~$2,700/dose | Save ~$2,630/dose |
| Costco | ~$2,600/dose | Save ~$2,530/dose |
Specialty Pharmacy | ~$3,000/dose | Save ~$2,930/dose |
*Just a heads-up — retail prices are estimates based on public data and vary by pharmacy. AffordMyPrescriptions Advocacy Service bypasses this by using drug manufacturer programs to secure your medication directly at no cost or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Adakveo Prescription Program?
PAP at no cost. Hydroxyurea (generic, very cheap) is foundational SCD therapy and dramatically lower cost.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Adakveo:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Coupon cards expire and require constant renewal
Still $2,500–$4,000/dose per month even with the best discount
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly through the assistance program
- We manage all paperwork, refills, and annual renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Adakveo assistance.
- You Are A U.S. Citizen Or Legal Resident
- You Have A Valid Adakveo Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Not sure if you qualify? Our pre-qualification check is completely free. If we can’t help, you won’t be charged.
Understanding Adakveo:
Adakveo is a humanized monoclonal antibody against P-selectin used for prevention of vaso-occlusive crises (VOC) in sickle cell disease. NOTE: A confirmatory phase 3 trial (STAND) failed to show benefit, leading EMA to withdraw approval in 2023. FDA approval status is under ongoing review. Discuss with hematologist whether Adakveo remains appropriate.
How Adakveo Works:
Vaso-occlusive crises in SCD involve sickled RBCs, activated WBCs/platelets, and endothelial cells aggregating in microvasculature — causing painful tissue ischemia. P-selectin on activated endothelium and platelets mediates this aggregation. Crizanlizumab binds P-selectin and blocks its interaction with PSGL-1 — reducing cellular adhesion that drives VOCs. The original SUSTAIN trial showed reduced VOC frequency vs placebo. However, the confirmatory phase 3 STAND trial failed to show benefit — leading EMA to withdraw approval. FDA’s review is ongoing.
Form and use:
Adakveo given as IV infusion over 30 minutes — first 2 doses 2 weeks apart, then monthly. Weight-based dose 5 mg/kg.
Generic availability:
No biosimilar. Foundational SCD therapy: hydroxyurea (generic, very cheap, evidence base for VOC prevention and hospitalization reduction). Other SCD options: L-glutamine (Endari), voxelotor (Oxbryta — FDA-withdrawn 2024 due to safety), stem cell transplant, gene therapy (Casgevy/exa-cel, Lyfgenia/lovo-cel — curative options for severe SCD).
Warnings:
Adakveo carries warnings for infusion-related reactions, interference with platelet count measurements (some automated cell counters give falsely low platelet count due to platelet clumping with Adakveo), and embryo-fetal considerations.
FAQ (Frequently Asked Questions)
Cost?
$2,500–$4,000/infusion. PAP at no cost. Hydroxyurea generic foundational SCD therapy very cheap.
Is Adakveo still recommended?
Status uncertain. EMA withdrew approval after confirmatory STAND trial failed to show benefit. FDA approval is under review. Discuss with hematologist whether Adakveo remains appropriate based on current evidenceYes, clinically. The FDA approves biosimilars only after demonstrating no clinically meaningful differences from the reference product (Actemra). Tofidence and Tyenne are FDA-approved tocilizumab biosimilars with the same indications and similar dosing, at substantially lower cost. Most rheumatologists are comfortable prescribing tocilizumab biosimilars.
Hydroxyurea?
Generic hydroxyurea is foundational SCD therapy — proven to reduce VOC frequency, reduce hospitalizations, reduce mortality. Very cheap ($10–$30/month). All SCD patients without contraindications should be on optimized hydroxyurea.
Gene therapy?
Casgevy (exa-cel) and Lyfgenia (lovo-cel) are FDA-approved gene therapies for severe SCD — one-time curative treatments costing $2–3 million but potentially eliminating SCD complications. Available at specialized centers.
Stem cell transplant?
Allogeneic HSCT (especially with matched sibling donor) can cure SCD. Considered for select severe SCD patients with appropriate donor.
Pregnancy?
Limited safety data with Adakveo. Hydroxyurea contraindicated in pregnancy (teratogenic) — switch to chronic transfusion in pregnancy if needed
What If My Application Is Denied?
Optimize hydroxyurea (generic, very cheap). L-glutamine (Endari). Consider stem cell transplant or gene therapy referral for severe disease. SCDAA foundation may help.
Take Control of Your Medication Costs
If struggling with Adakveo cost, discuss alternatives with your hematologist given changing evidence — generic hydroxyurea is foundational. Check eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.