HIZENTRA (immune globulin subcutaneous, 20%) Patient Assistance Program
Don’t let the high cost of brand specialty immune globulin therapy stand between you and the treatment you need. We help eligible patients access Hizentra (immune globulin subcutaneous, 20%) for as little as $69.95 per month through the manufacturer’s Patient Assistance Program.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Hizentra (immune globulin subcutaneous, human, 20%) is FDA-approved for primary immunodeficiency (PI) in adult and pediatric patients 2 years and older, and as maintenance therapy for adults with chronic inflammatory demyelinating polyneuropathy (CIDP) to prevent relapse.
- Without assistance, Hizentra costs vary by weight and dose: typical out-of-pocket cost runs approximately $6,000–$12,000 per month depending on body weight, with annual costs commonly $80,000+ for full replacement therapy.
- Through AffordMyPrescriptions, qualifying patients can access Hizentra for a flat $69.95 per month — our advocacy team manages the entire enrollment, refills, and renewal process.
- There is no FDA-approved generic or biosimilar version of Hizentra available in the U.S. as of 2026 — Hizentra is a plasma-derived biologic with no generic-equivalent pathway.
What is Hizentra Prescription Assistance Program?
The Hizentra Prescription Assistance Program is a manufacturer-sponsored initiative that provides Hizentra at little or no medication cost to qualifying patients based on income and insurance status. The program is designed for PI and CIDP patients who are uninsured or underinsured, as well as Medicare Part D beneficiaries.
Navigating the program on your own means dealing with eligibility verification, immunology/neurology coordination, infusion pump training documentation, specialty pharmacy logistics, and renewal deadlines.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your enrollment, from initial application through ongoing refill coordination and annual re-certification — so you focus on your health, not paperwork.
Pharmacy Price Comparison
- Without assistance, Hizentra costs are weight-based and commonly run $6,000–$12,000 per month. Discount coupons are not the right tool for a plasma-derived specialty biologic. A Patient Assistance Program is the meaningful path forward — if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Per gram (specialty pharmacy) | ~$120.00 | Save per gram |
| Typical 70 kg adult/month | ~$8,500.00 | Save ~$8,430/mo |
| Higher weight (~100 kg) | ~$12,000.00 | Save ~$11,930/mo |
| Pediatric (~30 kg) | ~$3,500+ | Save thousands/mo |
| Annual cost (typical adult) | ~$100,000+ | Save ~$99,000+/yr |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. Afford My Prescriptions Advocacy Service bypasses retail pricing by using drug manufacturer programs to secure your medication for you—independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Hizentra Prescription Program?
The Patient Assistance Program is free to apply for and provides Hizentra at no medication cost if approved. But the process involves detailed applications, immunology or neurology coordination, infusion pump training documentation, specialty pharmacy logistics, and ongoing renewal management. Our $69.95/month service covers full advocacy: applications, doctor coordination, training documentation, refill management, and annual re-enrollment — so you focus on your health, not paperwork.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through AffordMyPrescriptions is the better long-term solution for Hizentra:
Limitations of Coupons
Prices fluctuate — savings aren’t guaranteed month-to-month
Copay accumulators may prevent savings from counting toward your deductible
Coupon cards expire and require constant renewal
Still $6,000–$12,000 per month even with the best discount
Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly through the assistance program
We manage all paperwork, refills, and annual renewals
Medicare Part D patients accepted
DO YOU QUALIFY?
Eligibility is generally determined by annual household income and insurance status. Most programs follow guidelines that include limits of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because requirements vary by program and household, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for Hizentra assistance.
- You are a U.S. citizen or legal resident
- You Have A Valid Hizentra Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured, Underinsured, Or A Medicare Part D Beneficiary
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Hizentra:
Hizentra (immune globulin subcutaneous, human, 20%) is a plasma-derived biologic medicine used to treat primary immunodeficiency (PI) — a group of disorders in which the body cannot make enough of certain antibodies — and as maintenance therapy for chronic inflammatory demyelinating polyneuropathy (CIDP). It is given by subcutaneous infusion using a small pump, typically weekly or biweekly.
How It Works:
Hizentra is a concentrated solution of human immunoglobulin G (IgG) that provides essential antibodies to patients with primary immunodeficiency. For those with CIDP, it helps modulate the immune system to prevent nerve damage and reduce relapses. The medication works by replacing missing antibodies to fight infections or by balancing the immune response in autoimmune conditions. Its high concentration allows for effective subcutaneous delivery, helping patients manage their health from home.
Form and Use:
This treatment is administered via subcutaneous infusion using a small, portable pump that patients can operate at home after nursing training. For primary immunodeficiency, dosing is usually scheduled weekly or biweekly based on the patient’s weight and antibody levels. For CIDP maintenance, weekly dosing is the standard approach to maintain stability. The self-administration process offers flexibility and convenience for long-term therapy.
Generic Availability:
There are no generic versions of Hizentra because plasma-derived biologics do not have standard generic-equivalent pathways under FDA regulations. While no generic exists, there are other branded subcutaneous products like Cuvitru and Xembify, as well as intravenous options. Choosing between these branded products depends on a patient’s specific medical indication, clinical fit, and prior tolerance to treatment.
Warnings:
Hizentra carries important warnings regarding the risk of blood clots (thrombosis), renal dysfunction, and aseptic meningitis syndrome. It is contraindicated for patients with selective IgA deficiency who have specific antibodies against IgA. Patients should monitor for and report symptoms such as leg swelling, breathing difficulties, or severe headaches to their medical team immediately. Other rare but serious risks include lung injury and the breakdown of red blood cells.
FAQ (Frequently Asked Questions)
How Much Does Hizentra Cost Without Insurance?
Hizentra costs are weight-based. A typical 70 kg adult on PI dosing pays approximately $8,500/month at retail prices, with higher-weight patients reaching $12,000+/month. Annual costs commonly exceed $100,000 for full replacement therapy. Through AffordMyPrescriptions, qualifying patients receive Hizentra at no medication cost — our $69.95 monthly fee covers full advocacy and program management.
How Is Hizentra Given?
Hizentra is given by subcutaneous infusion at home using a small portable pump. For PI, dosing is typically weekly or biweekly based on body weight and IgG trough levels. For CIDP maintenance, weekly dosing of 0.2–0.4 g/kg is common. Patients are trained on the infusion technique by a specialty nurse before starting at-home therapy.
Are There Other Immune-Globulin Options I Should Know About?
Yes. Other subcutaneous immune-globulin products (Cuvitru, HyQvia, Cutaquig, Xembify) and intravenous immune globulin (IVIG) products are available. Whether one is a better clinical fit depends on the indication, prior tolerance, infusion-site reactions, and lifestyle factors. We mention this directly because if a different IG product on a more accessible assistance pathway would work for your situation, that may be a better path.
Can I Get Hizentra Through The PAP If I Have Medicare?
Yes. Medicare beneficiaries can typically qualify for Hizentra Patient Assistance, especially if you face significant out-of-pocket costs under medical or pharmacy benefits. Note: subcutaneous immune globulin coverage under Medicare can be complex (Part B vs. Part D depending on setting) — our advocates will help navigate the path that works for you
Is Hizentra Made From Human Plasma?
Yes. Hizentra is purified from human plasma collected from thousands of donors. The manufacturing process includes multiple viral inactivation and removal steps to ensure safety. Patients with selective IgA deficiency who have antibodies against IgA should not receive Hizentra.
What If My Application Is Denied?
If your initial application is denied, we explore alternative savings paths on your behalf — including independent foundations such as the PAN Foundation, HealthWell Foundation, the Immune Deficiency Foundation, or the GBS-CIDP Foundation, the manufacturer’s copay assistance program if you have commercial insurance, or asking your specialist whether a different IG product on a more accessible cost path would be appropriate. If we cannot find a path, you will not be charged our service fee.
Take Control of Your Medication Costs
If you are struggling with the high cost of Hizentra, our team may be able to help you access assistance programs designed to make brand specialty immune globulin therapy affordable. Check your eligibility today.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.