RELISTOR (methylnaltrexone) Patient Assistance Program
Don’t let opioid-induced constipation undermine your pain control. We help eligible patients access Relistor (methylnaltrexone) for as little as $69.95 per month through manufacturer Patient Assistance Programs.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Relistor Is Specifically Designed To Treat Constipation Caused By Opioid Pain Medications — Without Reducing Pain Relief
- Retail Cost Is Approximately $2,449–$2,717 For 90 Tablets Or $185–$1,285 Per Injection Without Insurance
- AffordMyPrescriptions Provides Access To Relistor For Just $69.95/Month Through The Patient Assistance Program
- No Generic Version Of Methylnaltrexone Is Currently Commercially Available
What is Relistor Prescription Assistance Program?
The Relistor Prescription Assistance Program is a manufacturer-sponsored initiative that provides Relistor at no medication cost to qualifying patients who cannot afford it. The program is available to U.S. citizens and legal residents. A copay savings card is also available for commercially insured patients, reducing out-of-pocket costs to as little as $0 per prescription with up to $800 in savings per fill.
Opioid-induced constipation is one of the cruelest ironies in medicine — the medication that finally controls your chronic pain creates a new, intensely uncomfortable problem. When traditional laxatives fail and your doctor prescribes Relistor because you need a medication that targets the root cause of opioid constipation, discovering that it costs over $2,400 for a 3-month supply can feel like punishment for needing pain management.
AffordMyPrescriptions ensures the targeted relief Relistor provides is accessible to every patient who needs it. For a flat $69.95 per month, our Patient Advocates manage every step of your enrollment.
Pharmacy Price Comparison
- Without assistance, Relistor costs significantly more at retail pharmacies than through our advocacy service. Discount programs offer some relief, but they don't come close to what a Patient Assistance Program provides, if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$2,500.00 | Save ~$2,430/mo |
| CVS Pharmacy | ~$2,449.00 | Save ~$2,379/mo |
| Walmart | ~$2,460.00 | Save ~$2,390/mo |
| Costco | ~$2,470.00 | Save ~$2,400/mo |
| Kroger | ~$2,455.00 | Save ~$2,385/mo |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. Afford My Prescriptions Advocacy Service bypasses retail pricing by using drug manufacturer programs to secure your medication for you—independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Relistor Prescription Program?
Managing chronic pain with opioids is already complex and emotionally draining — and when opioid-induced constipation adds another layer of suffering on top of the pain itself, the last thing you need is a financial barrier standing between you and the targeted relief your doctor has prescribed. Traditional laxatives didn’t fail because you used them wrong; they failed because they don’t address the specific mechanism by which opioids shut down your bowels.
From the moment you enroll, your advocate takes full ownership of your case. They prepare your application, coordinate with your prescribing physician, submit everything to the appropriate program, and track your status through each stage. When your medication is due for refill, they coordinate proactively so you never experience a gap.
Our pricing is simple and predictable: $69.95 per month — every month, without exception. While the medication itself is provided at no cost through the manufacturer’s program, our monthly fee covers all advocacy, application management, doctor coordination, and refill oversight. If we’re unable to secure access, you won’t be charged.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through Afford My Prescriptions is the better long-term solution:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Cards expire and require constant renewal
Still $2,449+/month even with best discount
- Cannot be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
Medication supplied directly from the manufacturer
We manage all paperwork, refills, and renewals
Medicare Part D patients accepted
DO YOU QUALIFY?
Eligibility is generally determined by annual household income levels. Most programs follow guidelines that include a limit of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because these requirements can vary, we encourage you to contact Afford My Prescriptions directly so we can review your specific situation.
- You are a U.S. citizen or legal resident
- You Have A Valid Relistor Prescription From A Licensed U.S. Healthcare Provider
- You Are Currently Taking Opioid Pain Medication And Experiencing Opioid-Induced Constipation
- You Are Uninsured, Underinsured, Or Have Experienced Financial Hardships
- Medicare Part D Patients May Also Be Eligible
Understanding Relistor:
Relistor (methylnaltrexone bromide) is a prescription medication used to treat opioid-induced constipation (OIC) in adults. It is available as oral tablets (150 mg, taken once daily) for adults with chronic non-cancer pain, and as subcutaneous injections (8 mg or 12 mg) for patients with advanced illness or cancer-related pain requiring palliative care. Critically, Relistor blocks the constipation-causing effects of opioids in the gut without interfering with pain relief in the brain.
How It Works:
Opioid medications bind to receptors in the gastrointestinal tract, slowing down muscle contractions and causing the gut to become effectively paralyzed. Relistor uses methylnaltrexone to specifically block these receptors in the gut without crossing the blood-brain barrier. This allows the medication to restore normal digestion and movement while ensuring your pain relief in the brain remains unaffected.
Form and Use:
Relistor is available as 150 mg oral tablets and subcutaneous injections in 8 mg or 12 mg doses. Tablets should be taken once daily on an empty stomach, at least 30 minutes before your first meal. Injections are administered under the skin in areas such as the upper arm, abdomen, or thigh for effective delivery.
Generic Availability:
As of April 2026, there is no generic version of Relistor commercially available at U.S. pharmacies for either the tablet or injection forms. While other medications in the same class like Movantik and Symproic exist, they are different drugs with separate pricing. Patients can currently access Relistor through the AffordMyPrescriptions Patient Assistance Program for a monthly fee of $69.95
Warnings:
This medication should not be used by individuals who have a known bowel blockage. If you experience severe, persistent stomach pain, it may indicate a tear in the intestinal wall and requires immediate emergency medical attention. Common side effects to monitor include abdominal pain, nausea, sweating, and diarrhea.
FAQ (Frequently Asked Questions)
How Much Does Relistor Cost Without Insurance?
Relistor tablets cost approximately $2,449–$2,717 for 90 tablets (3-month supply). Relistor injections cost approximately $185–$1,285 depending on dose and quantity. Through AffordMyPrescriptions, qualifying patients receive Relistor at no medication cost — our $69.95 monthly fee covers advocacy and program management.
Will Relistor Affect My Pain Relief?
No. Relistor is specifically designed to block opioid receptors only in the gut — it does not cross the blood-brain barrier, so it cannot interfere with the pain-relieving effects of your opioid medication. You maintain your pain control while restoring your bowel function.
Is This The Same Relistor I'd Get At A Pharmacy?
Yes. The Relistor supplied through the Patient Assistance Program is the same FDA-approved methylnaltrexone bromide medication dispensed at retail pharmacies, supplied directly from the manufacturer.
Is There A Generic Version Of Relistor?
Not yet commercially available. The FDA has approved generic methylnaltrexone, but it has not reached pharmacy shelves. Patent protections on certain Relistor formulations extend into the early 2030s.
Can I Get Relistor Through The PAP If I Have Medicare?
Yes. Medicare Part D patients may qualify for the Patient Assistance Program. As of 2026, Medicare Part D plans also have a $2,100 annual out-of-pocket cap, providing additional protection. Our advocates can help you evaluate the best pathway.
What if my application is denied?
Our Patient Advocates will immediately explore every alternative — including the manufacturer’s $0 copay card (for commercially insured patients), GoodRx coupons, naloxegol (Movantik) as an alternative oral OIC medication, naldemedine (Symproic), insurance prior authorization appeals, and Medicare Part D coverage pathways.
Take Control of Your Medication Costs
If you are struggling with the high cost of Relistor, our team may be able to help you access assistance programs designed to make medications more affordable. Check your eligibility today and take the first step toward reducing your prescription costs
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.