ORILISSA PATIENT ASSISTANCE PROGRAM
Don’t let the cost of endometriosis treatment force you to live with chronic pain. We help
eligible patients access Orilissa (elagolix) for as little as $69.95 per month through
manufacturer Patient Assistance Programs.
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Orilissa Is The First Oral Medication Specifically Approved For Moderate To Severe Endometriosis Pain — Offering Targeted Relief Without Surgery For The 11% Of American Women Living With Endometriosis
- Retail Price Is Approximately $1,194–$1,701/Month Without Insurance, And There Is No Generic — Making It One Of The Most Expensive Daily Oral Medications For A Chronic Pain Condition
- AffordMyPrescriptions Provides Access To Orilissa For Just $69.95/Month Through The Patient Assistance Program
- No Generic Version Of Elagolix Is Available, And Orilissa Remains Patent-Protected With No Specific Timeline For Generic Entry
What is ORILISSA Prescription Assistance Program?
The Orilissa Prescription Assistance Program is a manufacturer-sponsored initiative that provides Orilissa at no medication cost to qualifying patients who cannot afford it. The program provides up to 12 months of medication at no cost if approved, and patients can reapply as needed. Patients with insurance or Medicare Part D may also be eligible as exceptions on a case-by-case basis.
Endometriosis is more than period pain — it’s a chronic disease where tissue similar to the uterine lining grows outside the uterus, causing inflammation, scarring, and pain that can disrupt your ability to work, maintain relationships, and live your daily life. The average woman waits 7 to 10 years from symptom onset to diagnosis, and when a targeted treatment like Orilissa is finally prescribed, a $1,200+/month price tag can feel like yet another barrier.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates handle every step of your enrollment.
Medicare Part D patients accepted. If you have Medicare Part D coverage, you may still qualify for the Patient Assistance Program through case-by-case exceptions.
Pharmacy Price Comparison
- Without Assistance, Otezla Costs Thousands Of Dollars Per Month At Specialty Pharmacies. Discount Programs Offer Modest Relief For This Specialty Medication, But They Don't Come Close To What A Patient Assistance Program Provides, If You Qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$1,280.00 | Save ~$1210.05/mo |
| CVS Pharmacy | ~$1,300.00 | Save ~$1230.05/mo |
| Walmart | ~$1,250.00 | Save ~$1180.05/mo |
| Costco | ~$1,220.00 | Save ~$1150.05/mo |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. Afford My Prescriptions Advocacy Service bypasses retail pricing by using drug manufacturer programs to secure your medication for you—independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Otezla? Prescription Program ?
The Patient Assistance Program is free to apply and provides medication at no cost if approved. But the process involves detailed applications, prescriber coordination, documentation, and ongoing management. Our $69.95/month covers full advocacy: applications, doctor coordination, documentation, refill management, and re-enrollment — so you focus on your health, not paperwork.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here's why the Patient Assistance Program through Afford My Prescriptions is the better long-term solution:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Cards expire and require constant renewal
- Subject to strict monthly or annual maximum savings caps
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly from the manufacturer
- We manage all paperwork, refills, and renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income levels. Most programs follow guidelines that include a limit of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because these requirements can vary, we encourage you to contact Afford My Prescriptions directly so we can review your specific situation and determine if you qualify for assistance.
- You are a U.S. citizen or legal resident
- You Have A Valid Lokelma Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured Or Underinsured And Cannot Afford Your Medication At Current Pharmacy Prices
- You Have Medicare Part D Coverage (Accepted On Case-By-Case Basis)
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Orilissa:
Orilissa (elagolix) is a prescription oral tablet used to treat moderate to severe pain associated with endometriosis in women. It is the first oral GnRH antagonist approved specifically for endometriosis pain, offering a non-surgical treatment option for this debilitating chronic condition. Available in two dosing regimens: 150 mg taken once daily (for up to 24 months) and 200 mg taken twice daily (for up to 6 months), with the appropriate dose and duration determined by your doctor based on symptom severity and treatment goals.
How it works:
Endometriosis pain is driven by estrogen — the hormone that stimulates the misplaced endometrial tissue to grow, bleed, and cause inflammation each month. Your body produces estrogen through a hormonal cascade beginning in the brain: the hypothalamus releases GnRH (gonadotropin-releasing hormone), which signals the pituitary to release FSH and LH, which in turn stimulate the ovaries to produce estrogen.
Orilissa works by directly blocking the GnRH receptors in the pituitary gland — the critical relay point in this cascade. By blocking these receptors, Orilissa partially suppresses the hormone signals that tell your ovaries to produce estrogen. The key word is ‘partially’ — and this is what makes Orilissa different from older treatments like Lupron. Unlike GnRH agonists that initially overstimulate and then completely shut down estrogen production, Orilissa as a GnRH antagonist provides immediate, dose-dependent suppression. The 150 mg once-daily dose partially lowers estrogen — enough to reduce endometriosis pain while maintaining some estrogen activity. The 200 mg twice-daily dose provides greater estrogen suppression for more severe pain.
Form and use:
Available in 150 mg (once daily for up to 24 months) and 200 mg (twice daily for up to 6 months) doses. Take orally with or without food. Non-hormonal contraception is required during treatment.
Generic availability:
As of April 2026, there is no generic version of Orilissa (elagolix) available in the United States. Orilissa remains patent-protected, and no specific timeline for generic entry has been established. The same active ingredient, elagolix, is also used in Oriahnn (combined with estradiol and norethindrone acetate)
for uterine fibroid-related heavy bleeding — but Oriahnn is a separate product with different dosing and indication.
Warnings:
Do not use if pregnant. Non-hormonal contraception required during treatment. May affect bone density with long-term use; your doctor may recommend bone density monitoring. Suicidal ideation and mood changes have been reported. Tell your doctor about any history of liver disease or osteoporosis before starting therapy.
FAQ (Frequently Asked Questions)
How Much Does Orilissa Cost Without Insurance?
Orilissa costs approximately $1,130–$1,701/month. The manufacturer offers a $5/month copay savings card for commercially insured patients (max $5,000/year). Through
AffordMyPrescriptions, qualifying patients receive Orilissa at no medication cost — our $69.95 monthly fee covers advocacy and program management.
Is This The Same Orilissa I'd Get At A Pharmacy?
Yes. Orilissa obtained through the Patient Assistance Program is the same FDA-approved tablet manufactured by the same company that you would receive at any pharmacy.
Is There A Generic Version Of Orilissa?
No. As of April 2026, no generic elagolix is available. Orilissa remains patent-protected with no specific timeline for generic entry.
Why Are There Two Different Doses Of Orilissa?
Orilissa 150 mg once daily provides partial estrogen suppression and can be taken for up to 24 months. Orilissa 200 mg twice daily provides greater estrogen suppression for more severe pain but is limited to 6 months due to the impact of deeper estrogen suppression on bone density. Your doctor will choose the dose based on your pain severity and treatment goals.
What If My Application Is Denied?
Our Patient Advocates immediately explore every alternative — including the manufacturer’s $5 copay savings card (commercially insured), GoodRx and SingleCare coupons, Myfembree as an alternative oral GnRH antagonist, Lupron Depot as an injectable option, generic norethindrone acetate ($15–$30/month), generic hormonal contraceptives, and insurance prior authorization and formulary exception appeals.
Can I Get Orilissa Through The PAP If I Have Medicare?
Our Patient Advocates immediately explore every alternative — including the manufacturer’s $5 copay savings card (commercially insured), GoodRx and SingleCare coupons, Myfembree as an alternative oral GnRH antagonist, Lupron Depot as an injectable option, generic norethindrone acetate ($15–$30/month), generic hormonal contraceptives, and insurance prior authorization and formulary exception appeals.
Take Control of Your Medication Costs
If you are struggling with the high cost of Orilissa, our team may be able to help you access assistance programs designed to make medications more affordable. Check your eligibility today and take the first step toward reducing your prescription costs.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.