DEMSER Patient Assistance Program
Don’t let the cost of a rare-disease medication endanger your health. We help eligible patients access Demser (metyrosine) for as little as $69.95 per month through manufacturer Patient Assistance Programs..
- Clear & Transparent Pricing
- Paperwork & Doctor-Coordination
- Comprehensive Support: From Application to Entire Journey
- Annual Re-certification And Refills Management
- Medicare Part D Patients Accepted
HIPAA Compliant
BBB Accredited
Secure Website
Key Takeaways:
- Demser Is The Only Medication Specifically Designed To Reduce Catecholamine Production At Its Source In Pheochromocytoma — A Rare, Potentially Life-Threatening Adrenal Gland Tumor Affecting An Estimated 500–1,600 People Per Year In The U.S.
- Retail Price Is Approximately $44,715 For 100 Capsules Of Brand-Name Demser, While Generic Metyrosine Costs $3,856–$11,461 For 30–120 Capsules With Coupons
- AffordMyPrescriptions Provides Access To Demser For Just $69.95/Month Through The Patient Assistance Program — Medicare Part D Patients Accepted
- A Generic Version Of Metyrosine Is Available But Remains Extraordinarily Expensive Due To The Ultra-Rare Patient Population
What is DEMSER Prescription Assistance Program?
The Demser Prescription Assistance Program is a manufacturer-sponsored initiative that provides Demser at no medication cost to qualifying patients. The program is available for up to 6 months and may be renewed. A copay savings offer is also available for eligible patients, limiting out-of-pocket costs to no more than $25 per month. Insurance coverage research and medication delivery directly to your home are included as part of the comprehensive support program.
Pheochromocytoma is one of the most frightening rare disease diagnoses — a tumor that floods your body with adrenaline, causing sudden episodes of dangerously high blood pressure, pounding heartbeat, profuse sweating, and severe headaches that can strike without warning and, in the worst cases, trigger a stroke or heart attack. Discovering that your lifesaving medication costs tens of thousands of dollars can compound the terror of an already overwhelming diagnosis.
AffordMyPrescriptions eliminates that burden. For a flat $69.95 per month, our Patient Advocates specialize in navigating the unique challenges of rare disease medication access — managing every step of your enrollment, from initial application through ongoing refills, home delivery logistics, and re-enrollment every 6 months, so you never face a gap in your catecholamine control therapy. Medicare Part D patients are accepted.
Pharmacy Price Comparison
- Without assistance,Demser can cost hundreds — or even thousands — of dollars per month at retail pharmacies. Discount programs offer some relief, but they don't come close to what a Patient Assistance Program provides, if you qualify:
| Pharmacy(With Coupon) | PrIce (30-Day)* | You Save W/ Us |
|---|---|---|
| Walgreens | ~$11,461 | Save~$11,461 |
| CVS Pharmacy | ~$11,461 | Save~$11,391/mo |
| Walmart | ~$11,461 | Save ~$11,430/mo |
| Costco | ~$11,460 | Save ~$11,390/mo |
| Kroger | ~$11,475 | Save ~$11,405/mo |
*Retail prices are estimates based on public data and vary by pharmacy. Coupon prices from GoodRx and SingleCare as of April 2026. Afford My Prescriptions Advocacy Service bypasses retail pricing by using drug manufacturer programs to secure your medication for you—independent of dosage or retail price.
Our Pricing:
$69.95 Per month
1 Medications
$79.95 Per Month
2 Medications
$89.95 Per Month
3 Medications
$99.95 Per Month
4+ Medications
Why choose us For Your Demser Prescription Program?
The Patient Assistance Program is free to apply for and provides medication at no cost if approved. But the process involves detailed applications, prescriber coordination, documentation, and ongoing management. Our $69.95/month covers full advocacy: applications, doctor coordination, documentation, refill management, and re-enrollment — so you focus on your health, not paperwork.
Enroll
Complete a simple eligibility form so our team can determine if you may qualify for medication assistance programs.
We Advocate
Our specialists help gather documentation, complete applications, and coordinate with program providers.
Receive Medication
Once approved, you may receive your medication through the assistance program while we help manage ongoing paperwork and renewals.
Discount Coupons vs. Patient Assistance Programs
Many patients try discount cards first. Here’s why the Patient Assistance Program through Afford My Prescriptions is the better long-term solution:
Limitations of Coupons
- Prices fluctuate — savings aren’t guaranteed month-to-month
- Copay accumulators may prevent savings from counting toward deductible
- Cards expire and require constant renewal
- Subject to strict monthly or annual maximum savings caps
- Can’t be used with Medicare, Medicaid, or government insurance
Advantages of PAP Through Us
- Fixed $69.95/month — never changes regardless of retail price
- No expiration — continuous access as long as you qualify
- Medication supplied directly from the manufacturer
- We manage all paperwork, refills, and renewals
- If denied, we explore alternative savings on your behalf
DO YOU QUALIFY?
Eligibility is generally determined by annual household income levels. Most programs follow guidelines that include a limit of up to $40,000 for individuals, $60,000 for couples, and $100,000 for larger families. Because these requirements can vary, we encourage you to contact AffordMyPrescriptions directly so we can review your specific situation and determine if you qualify for assistance.
- You are a U.S. citizen or legal resident
- You Have A Valid Demser Prescription From A Licensed U.S. Healthcare Provider
- You Are Uninsured Or Underinsured And Cannot Afford Your Medication At Current Pharmacy Prices
- You Are Enrolled In Medicare Part D (Case-By-Case Eligibility)
- You Have Recently Experienced A Change In Financial Circumstances That Affects Your Ability To Pay
Understanding Demser:
Demser (metyrosine) is a prescription oral capsule used to treat pheochromocytoma — a rare tumor of the adrenal gland that causes dangerously excessive production of catecholamines (adrenaline and noradrenaline), leading to severe high blood pressure, rapid heartbeat, intense sweating, and potentially life-threatening cardiovascular crises. Demser is used for preoperative preparation of patients for surgery, management of patients when surgery is not possible, and chronic treatment of patients with malignant pheochromocytoma. It is approved for patients age 12 and older. The typical starting dose is 250 mg taken by mouth 4 times daily, with doses adjusted based on response up to a maximum of 4 grams per day
How It Works:
In pheochromocytoma, the tumor cells in your adrenal gland produce dangerously excessive amounts of catecholamines — the hormones adrenaline (epinephrine) and noradrenaline (norepinephrine). These hormones are manufactured inside tumor cells through an enzyme pathway that begins with an amino acid called tyrosine. The first and rate-limiting step in this pathway is performed by an enzyme called tyrosine hydroxylase, which converts tyrosine into a precursor that is then converted into the catecholamines that cause your symptoms.
Demser works by directly inhibiting the tyrosine hydroxylase enzyme — essentially turning off the “faucet” that produces catecholamines at their source inside the tumor cells. By blocking this first step, Demser reduces the overall production of both adrenaline and noradrenaline by the tumor, decreasing the frequency and severity of the dangerous hypertensive episodes, rapid heartbeat, sweating, and other symptoms. Before surgery, this catecholamine reduction makes tumor removal dramatically safer by preventing the life-threatening catecholamine surges that can occur when the surgeon manipulates the tumor. For patients who cannot undergo surgery (due to metastatic disease or medical contraindications), Demser provides ongoing control of catecholamine production to manage symptoms and reduce cardiovascular risk.
Form and Use:
Available as 250 mg capsules. Typical starting dose is 250 mg taken by mouth 4 times daily. Your doctor will adjust your dose based on catecholamine levels measured through blood and urine tests, up to a maximum of 4 grams per day.
Generic Availability:
Generic metyrosine is available in the United States. However, due to the ultra-rare nature of pheochromocytoma (only an estimated 500 to 1,600 new cases per year), generic metyrosine remains extremely expensive — approximately $3,856 to $11,461 for 30–120 capsules with discount coupons, compared to $44,715 for 100 capsules of brand-name Demser. The limited patient population means few manufacturers produce metyrosine, keeping prices extraordinarily high even in generic form. The Patient Assistance Program through AffordMyPrescriptions provides brand-name Demser at no medication cost for $69.95 per month — the only realistic pathway to affordable access for most pheochromocytoma patients.
Warnings:
Do not stop taking Demser without medical supervision — sudden discontinuation can allow catecholamine production to surge back, triggering dangerous hypertensive episodes. Drink plenty of fluids while taking Demser to prevent urinary crystal formation. Avoid alcohol and sedating medications, as drowsiness is common especially when starting therapy. Tell your doctor about all medications you take, as Demser can interact with several drug classes.
FAQ (Frequently Asked Questions)
How Much Does Demser Cost Without Insurance?
Brand-name Demser costs approximately $44,715 for 100 capsules. Generic metyrosine ranges from $3,856 to $11,461 for 30–120 capsules with coupons. A manufacturer copay program limits costs to $25 per month for eligible insured patients, and the PAP provides medication at no cost for qualifying uninsured patients. Through AffordMyPrescriptions, qualifying patients receive Demser at no medication cost — our $69.95 monthly fee covers advocacy.
Is This The Same Demser I'd Get At A Pharmacy?
Yes. The Demser provided through the Patient Assistance Program is the identical FDA-approved brand-name medication dispensed at U.S. specialty pharmacies. It ships in the manufacturer’s original packaging directly to your home as part of the comprehensive support program.
Is There A Generic Version Of Demser?
Yes, generic metyrosine is available — however, due to the ultra-rare patient population (only 500–1,600 new cases per year in the U.S.), it remains extraordinarily expensive at port program approximately $3,856–$11,461 per month with coupons. For patients who cannot afford the generic, the PAP provides brand Demser at no medication cost through our service.
Can I Get Demser Through The PAP If I Have Medicare?
Yes. Medicare Part D beneficiaries are accepted through the manufacturer’s Patient Assistance Program. Our Patient Advocates handle the specific documentation required for Medicare patients and ensure your enrollment is processed without delay
What If My Application Is Denied?
Our Patient Advocates will immediately explore every alternative — including the manufacturer’s $25/month copay program (for insured patients), generic metyrosine at the best available coupon price, independent rare disease co-pay assistance foundations, insurance prior authorization appeals with documentation of pheochromocytoma diagnosis, Medicare or Medicaid pathways, and clinical trial enrollment for newer pheochromocytoma treatments. If we can’t help, you won’t be charged.
How Long Does It Take To Get Approved?
Rare-disease programs often approve faster than standard PAPs due to the urgent medical need. Most applications are reviewed within 2 to 4 weeks. During that time, your Patient Advocate gathers required documentation from you and your endocrinologist or oncologist and submits the complete application package. We track your status throughout and follow up if additional information is needed.
Take Control of Your Medication Costs
If you are struggling with the high cost of Crinone, our team may be able to help you
access assistance programs designed to make medications more affordable. Check
your eligibility today and take the first step toward reducing your prescription costs.
Submit Enrollment Form
Start free by filling out a simple online form.
Receive Welcome Call
Our specialist will contact you for a quick welcome call.
We Manage The Process
Our team handles everything, so you can focus on your health.